KBN grant No N N403 222239 (2010-2013)


Project Manager – Krzysztof Morawski, MD, PhD

"The development of the clinical use of models of morphological changes recorded in transtympanal electrocochleografy in the Fast stimulus presentation (to 1000/s) in cochlear and postcochlear damage of hearing organ"


Team:

  • prof. Kazimierz Niemczyk,
  • prof. Ozdamar Ozcan (University of Miami),
  • Catherine Pierchala MD, Ph.D.,
  • Marta Held – Ziółkowska MD, PhD,
  • Jacek Sokolowski MD ,
  • Alexander Hryciuk MD,
  • Jorge Bohorquez PhD (University of Miami)


The problem of diagnosis of sensorineural hearing loss in a typical audiometric tests is still open. Performed pure tone audiometry, impedance audiometry and otoacoustic emissions, as well as the implementation of the auditory evoked potentials of the brain stem usually gives significant insight as to the pathology, but it is not a complete picture of what we are dealing with. It is true that on the basis of such diagnosis we can be assume with a high degree of probability if the dominant component of damage is cochlear or postcochlear, however it is highly imprecise term. Does not allow us to define what kind of processes of peripheral part of hearing organ are damaged and what particular phenomenon of cochlear level are disrupted. In the end we have no chance to predict about the progress of damage of hearing organ.

One of the research techniques that are being developed and tested by scientists is testing of auditory evoked potentials in the option of fast stimulus presentation. The new technique of rapid stimulus presentation and analysis of the response records was developed by Delgado and Ozdamar (2004). It solves most of the problems associated with the frequency of the stimulus presentation greater than 100/s and generates impulses in the option of fast stimulus presentation (up to 1000/s) and allows averaging the received responses after the run of the" extract individual superimposed auditory response. "The mathematical model to extract individual records of a comprehensive response has been described by the authors of this technique Delgado and Ozdamar (J Acoust Soc Am 2004, 115:1242-1251) and then supplemented and enhanced by Ozdamar and Bohorquez (J Acoust Soc Am 2006, 119:429 -38). Both prof. Ozdamar and Bohorquez are co-authors of the presented project.

In accordance with the project's authors develop patterns of clinical hearing responses TT– ECochG and ABR for three pathologies:

  1. Tumor or other pathology of cerebello – pontine angle area - confirmed by computed tomography and magnetic resonance imaging with and without contrast,
  2. Meniere's disease with the confirmed diagnosis by patient history and audiological and otoneurological examination with exclusion of pathology of cerebellar pontine angle,
  3. Progressive sensorineural hearing loss in young people. In all patients is carried out an expanded imaging, otoneurological and audiological diagnostic. Finally, qualified patients are examined in electrophysiological techniques in CLAD option for clique stimulation and tone of a specific frequency at a rate of stimulus presentation to 800/s These results are compared with other audiological results. The appropriate statistical analysis of single and multi-factor will allow to elaborate changes of models in the electrophysiological recordings, which significantly will expand the opportunity to describe the phenomena occurring in the organ of hearing at the cochlea VIII nerve and brain stem. In the future, based on data compiled it will be possible to significantly expand the application of this technique to solve some of the problems in neonatology, neurology, otoneurology, anesthesia. But above all, more accurate diagnosis is the more accurate decision regarding treatment.